Kambo, a traditional Amazonian remedy with a rich history steeped in indigenous culture, has captivated the fascination of modern explorers seeking its therapeutic benefits. Originating from the Amazon rainforest, Kambo has been utilized for centuries by indigenous tribes, notably the Matses, Katukina, and Mayoruna, as a powerful tool for purification and healing. The origins of Kambo's usage trace back to ancient legend and tribal lore, where it is believed to have been imparted to shamans through divine revelation during ayahuasca ceremonies. Its discovery is often attributed to the Phyllomedusa bicolor frog, also known as the giant monkey frog or Kambo frog, whose secretion is harvested for its medicinal properties.

Traditionally, Kambo has been employed for various purposes within indigenous communities, ranging from hunting prowess and physical endurance to spiritual cleansing and medicinal treatment. It is administered ceremonially, with the application of Kambo typically performed by a trained shaman or healer known as "Kambo practitioner." Throughout history, Kambo has garnered a reputation for its multifaceted healing properties, believed to address a wide array of physical, mental, and emotional ailments. From alleviating pain and inflammation to purifying the body of toxins and negative energies, Kambo has been revered as a potent agent of transformation and renewal.